Yes. A customer is asked for their billing and shipping address during checkout. The shipping address is checked against the Shipping Method for the product or group of products in the order. When a Shipping Method for a product has a Shipping Zone that is outside the customer's shipping address, the product can't be purchased. To learn more, read the "How to add Shipping Zones" tutorial. Shipping Zones can be found in Store> Shipping> Zones.
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